Pathways
Bacterial Meningitis
Description:
Bacterial meningitis is an inflammation of the meninges, in particular the arachnoid and the pia mater, associated with the invasion of bacteria into the subarachnoid space.The pathogens take advantage of the specific features of the immune system in the CNS, replicate and induce inflammation. A hallmark of bacterial meningitis is the recruitment of highly activated leukocytes into the CSF.The predominant causative pathogens in adults are Streptococcuspneumoniae, Neisseriameningitidis, and Listeria monocytogenes which are respon...
References:
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Pathophysiology and treatment of bacterial meningitis.
Ther Adv Neurol Disord. 2009 Nov;2(6):1-7. doi: 10.1177/1756285609337975. -
Pathogenic Triad in Bacterial Meningitis: Pathogen Invasion, NF-?B Activation, and Leukocyte Transmigration that Occur at the Blood-Brain Barrier.
Front Microbiol. 2016 Feb 19;7:148. doi: 10.3389/fmicb.2016.00148. eCollection 2016. Review. -
Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury.
J Infect Dis. 2002 Dec 1;186 Suppl 2:S225-33. Review. -
Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury.
Nat Rev Neurosci. 2003 May;4(5):376-85. Review. No abstract available.
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