Pathways
BAD Phosphorylation
Description:
The ability of multicellular organisms to maintain cellular homeostasis is critically dependent on a balance between cell survival and cell death (apoptosis). The responsiveness of individual cells to death signals varies greatly depending on the presence of continuous survival cues from the extracellular environment. The perturbation of normal cell survival mechanisms, leading to an increase in cell survival or cell death plays an important role in the development of a number of disease states, including cancer. BAD (BCL2 Assoc...
References:
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Regulation of DNA fragmentation: the role of caspases and phosphorylation.
FEBS J. 2011 Feb;278(3):427-41. doi: 10.1111/j.1742-4658.2010.07975.x. Epub 2010 Dec 23. Review. -
Mitochondrial phosphorylation in apoptosis: flipping the death switch.
Antioxid Redox Signal. 2013 Aug 20;19(6):572-82. doi: 10.1089/ars.2012.4982. Epub 2012 Dec 7. Review. -
Anoikis molecular pathways and its role in cancer progression.
Biochim Biophys Acta. 2013 Dec;1833(12):3481-3498. doi: 10.1016/j.bbamcr.2013.06.026. Epub 2013 Jul 2. Review. -
MOMP, cell suicide as a BCL-2 family business.
Cell Death Differ. 2018 Jan;25(1):46-55. doi: 10.1038/cdd.2017.179. Epub 2017 Oct 20. Review.
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