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BAFF in B-Cell Signaling


BAFF (B-cell activating factor), is a member of the TNF (tumor necrosis factor) ligand family that plays important roles in B-cell homeostasis, tolerance, and malignancy (Ref.1). It is also known as BLyS (B lymphocyte stimulator) protein, TALL-1 (TNF and apoptosis ligand-related leukocyte-expressed ligand-1), zTNF4, CD257, TNFSF13B, TNFS20 (TNF superfamily member) and THANK (TNF homolog that activates apoptosis, NF-B and c-Jun NH2-terminal kinase). It functions through three receptors i.e. TACI, BCMA and BAFFR (BAFF-recepto...




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