BAFF in B-Cell Signaling

Description:

BAFF (B-cell activating factor), is a member of the TNF (tumor necrosis factor) ligand family that plays important roles in B-cell homeostasis, tolerance, and malignancy (Ref.1). It is also known as BLyS (B lymphocyte stimulator) protein, TALL-1 (TNF and apoptosis ligand-related leukocyte-expressed ligand-1), zTNF4, CD257, TNFSF13B, TNFS20 (TNF superfamily member) and THANK (TNF homolog that activates apoptosis, NF-B and c-Jun NH2-terminal kinase). It functions through three receptors i.e. TACI, BCMA and BAFFR (BAFF-recepto...

References:

Role of BAFF/BAFF-R axis in B-cell non-Hodgkin lymphoma.
Yang S, Li JY, Xu W.
Crit Rev Oncol Hematol. 2014 Aug;91(2):113-22. doi: 10.1016/j.critrevonc.2014.02.004. Epub 2014 Feb 23. Review.
Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures.
Gardam S, Brink R.
Front Immunol. 2014 Jan 6;4:509. doi: 10.3389/fimmu.2013.00509. eCollection 2014 Jan 6. Review.
Cracking the BAFF code.
Mackay
F, Schneider P.
B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.
Khan WN.
J Immunol. 2009 Sep 15;183(6):3561-7. doi: 10.4049/jimmunol.0800933. Review.

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Pathways

BAFF in B-Cell Signaling

Description:

References:

Role of BAFF/BAFF-R axis in B-cell non-Hodgkin lymphoma.

Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures.

Cracking the BAFF code.

B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.

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Tools

Institutional License

Pathways

BAFF in B-Cell Signaling

Description:

References:

Role of BAFF/BAFF-R axis in B-cell non-Hodgkin lymphoma.

Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures.

Cracking the BAFF code.

B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.

Databases

Tools

Institutional License

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