Pathways
Base Excision Repair Pathway
Description:
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents that result from either endogenous sources (cellular metabolic processes) or exogenous sources (environmental factors). Endogenous sources of DNA damage include hydrolysis, oxidation, alkylation, and mismatch of DNA bases; sources for exogenous DNA damage include ionizing radiation (IR), ultraviolet (UV) radiation, and various chemicals agents (Ref.1). Repairing damage in DNA from anything that causes a mutation, such as UV radia...
References:
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DNA-damage repair; the good, the bad, and the ugly.
EMBO J. 2008 Feb 20;27(4):589-605. doi: 10.1038/emboj.2008.15. Review. -
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae.
Genetics. 2013 Apr;193(4):1025-64. doi: 10.1534/genetics.112.145219. Review. -
DNA glycosylases: in DNA repair and beyond.
Chromosoma. 2012 Feb;121(1):1-20. doi: 10.1007/s00412-011-0347-4. Epub 2011 Nov 3. Review. -
Kinetic Methods for Studying DNA Glycosylases Functioning in Base Excision Repair.
Methods Enzymol. 2017;592:357-376. doi: 10.1016/bs.mie.2017.03.016. Epub 2017 Apr 26.
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