Pathways
BCR Pathway
Description:
The BCR (B-Cell antigen Receptor) plays a critical role in development, survival, and activation of B cells. The BCR is composed of mIg molecules (Membrane Immunoglobulin) and associated Ig-Alpha/Ig-Beta heterodimer [Ref.1]. The mIg subunits bind antigen and cause receptor aggregation, while the Alpha/Beta subunits transduce signals to the cell interior. Engagement of receptor activates three types of intracellular protein tyrosine kinases, SYK (Spleen Tyrosine Kinase), BTK (Bruton agammaglobulinemia Tyrosine Kinase) and several...
References:
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B-cell receptor: from resting state to activate.
Immunology. 2012 May; 136(1):21-7. doi: 10.1111/j.1365-2567.2012.03564.x. Review. -
Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation.
J Immunol. 2007 Feb 15; 178(4):2328-35. -
The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.
J Leukoc Biol. 2010 Jun; 87(6):1083-95. doi: 10.1189/jlb.0809585. Epub 2010 Mar 3. -
The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.
Mol Cell Biol. 2000 Feb; 20(4):1179-86.
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