Pathways
BDNF Pathway
Description:
Neurotrophins are an important class of signaling molecules in the brain responsible for axon targeting, neuron growth, maturation of synapses during development, and synaptic plasticity. This family of molecules includes NGF (Nerve Growth Factor), BDNF (Brain Derived Neurotrophic Factor), NT3 (Neurotrophin-3) and NT4 (Neurotrophin-4) [Ref.1].
Brain-derived neurotrophic factor (BDNF) is one of the neurotrophic factors that support differentiation, maturation, and survival of neurons in the nervous system and shows ...
References:
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Brain-derived neurotrophic factor and neuropsychiatric disorders.
Pharmacol Rev. 2012 Apr; 64(2):238-58. doi: 10.1124/pr.111.005108. Epub 2012 Mar 8. Review. -
Brain-derived neurotrophic factor and its clinical implications.
Arch Med Sci. 2015 Dec 10; 11(6):1164-78. doi: 10.5114/aoms.2015.56342. Epub 2015 Dec 11. -
A simple role for BDNF in learning and memory?
Front Mol Neurosci. 2010 Feb 9; 3:1. doi: 10.3389/neuro.02.001.2010. eCollection 2010. -
Neurobiology of local and intercellular BDNF signaling.
Pflugers Arch. 2017 Jun; 469(5-6):593-610. doi: 10.1007/s00424-017-1964-4. Epub 2017 Mar 9. Review. Erratum in: Pflugers Arch. 2017 Jun; 469(5-6):611.
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