Pathways
Beta-Adrenergic Signaling
Description:
The rate and strength of beating of the heart is under the reciprocal control of the Adrenergic (sympathetic) and Cholinergic (parasympathetic) systems. Increased strength (inotropy) in cardiac beating in response to hormones like the blood-borne Epinephrine or to neurally delivered Norepinephrine is mediated by ADR-Beta (Beta-Adrenergic Receptors) , which are members of the superfamily of cell surface receptors that carry out signaling via coupling to G-proteins (Guanine nucleotide binding proteins)(Ref.1). ADR forms the int...
References:
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Autonomic and endocrine control of cardiovascular function.
World J Cardiol. 2015 Apr 26;7(4):204-14. doi: 10.4330/wjc.v7.i4.204. Review. -
Adrenergic regulation of innate immunity: a review.
Front Pharmacol. 2015 Aug 13;6:171. doi: 10.3389/fphar.2015.00171. eCollection 2015. Review. -
Cardiac Effects of Attenuating Gsa - Dependent Signaling.
PLoS One. 2016 Jan 26;11(1):e0146988. doi: 10.1371/journal.pone.0146988. eCollection 2016. -
The role of CaMKII regulation of phospholamban activity in heart disease.
Front Pharmacol. 2014 Jan 27;5:5. doi: 10.3389/fphar.2014.00005. eCollection 2014. Review.
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