Pathways
G-Beta Gamma Signaling
Description:
G-proteins (Guanine Nucleotide-Binding Proteins) are heterotrimeric proteins that mediate signal transduction between many membrane-bound receptors and intracellular effectors. Traditionally, activation of heterotrimeric G-proteins is accomplished exclusively by the action of GPCRs (G-Protein Coupled Receptors), Seven transmembrane-spanning proteins that typically reside in the Plasma membrane. G-proteins consist of Alpha, Beta and Gamma subunits, and each is involved in signaling to distinct effectors. There are 20 different...
References:
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The expanding roles of Gß? subunits in G protein-coupled receptor signaling and drug action.
Pharmacol Rev. 2013 Feb 13;65(2):545-77. doi: 10.1124/pr.111.005603. Print 2013 Apr. Review. -
Structural Aspects of GPCR-G Protein Coupling.
Toxicol Res. 2013 Sep;29(3):149-55. doi: 10.5487/TR.2013.29.3.149. -
Membrane channels as integrators of G-protein-mediated signaling.
Biochim Biophys Acta. 2014 Feb;1838(2):521-31. doi: 10.1016/j.bbamem.2013.08.018. Epub 2013 Sep 9. Review. -
Structural insights into phospholipase C-ß function.
Mol Pharmacol. 2013 Oct;84(4):488-500. doi: 10.1124/mol.113.087403. Epub 2013 Jul 23. Review.
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