Biosynthesis of Arginine in Bacteria

Description:

In bacteria, biosynthesis of arginine proceeds from glutamate in eight enzymatic steps initiated by the acetylation of glutamate by N-Acetyl Glutamate Synthetase. The N-Acetylated intermediates lead to ornithine. The synthesis of ornithine, like that of proline, involves the activation and reduction of the 5-carboxyl group of glutamate. In prokaryotes the pathway of arginine biosynthesis follows two alternative patterns which differ by the strategies used for the removal of the acetyl group and for the control of the metaboli...

References:

Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms.
Xu Y, Labedan B, Glansdorff N.
Microbiol Mol Biol Rev. 2007 Mar;71(1):36-47. doi: 10.1128/MMBR.00032-06.
Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase.
de Cima S, Gil-Ortiz F, Crabeel M, Fita I, Rubio V.
PLoS One. 2012;7(4):e34734. doi: 10.1371/journal.pone.0034734. Epub 2012 Apr 18.
A novel type of N-acetylglutamate synthase is involved in the first step of arginine biosynthesis in Corynebacterium glutamicum.
Petri K, Walter F, Persicke M, Rückert C, Kalinowski J.
BMC Genomics. 2013 Oct 18;14:713. doi: 10.1186/1471-2164-14-713.
Argininosuccinate synthase: at the center of arginine metabolism.
Haines RJ, Pendleton LC, Eichler DC.
Int J Biochem Mol Biol. 2011;2(1):8-23.

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Pathways

Biosynthesis of Arginine in Bacteria

Description:

References:

Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms.

Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase.

A novel type of N-acetylglutamate synthase is involved in the first step of arginine biosynthesis in Corynebacterium glutamicum.

Argininosuccinate synthase: at the center of arginine metabolism.

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Institutional License

Pathways

Biosynthesis of Arginine in Bacteria

Description:

References:

Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms.

Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase.

A novel type of N-acetylglutamate synthase is involved in the first step of arginine biosynthesis in Corynebacterium glutamicum.

Argininosuccinate synthase: at the center of arginine metabolism.

Databases

Tools

Institutional License

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