Pathways
Biosynthesis of Glycine and Serine
Description:
Intermediates in energy production pathways such as glycolysis and the Krebs cycle are commonly the starting point for the biosynthesis of amino acids. The biosynthesis of serine and glycine constitute a major metabolic pathway that plays a central role in the formation of other amino acids, nucleic acids and phospholipids. Serine an É‘-amino acid used in the biosynthesis of proteins can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid. It contains an α-amino...
References:
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Links between Serine Biosynthesis Pathway and Epigenetics in Cancer Metabolism.
Clin Nutr Res. 2018 Jul;7(3):153-160. doi: 10.7762/cnr.2018.7.3.153. Epub 2018 Jul 26. -
L-serine synthesis in the central nervous system: a review on serine deficiency disorders.
Mol Genet Metab. 2010 Mar;99(3):256-62. doi: 10.1016/j.ymgme.2009.10.012. Epub 2009 Oct 25. -
Serine and glycine metabolism in cancer.
Trends Biochem Sci. 2014 Apr;39(4):191-8. doi: 10.1016/j.tibs.2014.02.004. Epub 2014 Mar 20.
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