Pathways
Biosynthesis of Isoleucine
Description:
Isoleucine encoded by the codons AUU, AUC, and AUA used in the biosynthesis of proteins. It is a α-amino acid that contains an α-amino group, an α-carboxylic acid group, and a hydrocarbon side chain. It is classified as a non-polar, uncharged (at physiological pH), branched-chain, aliphatic amino acid. Isoleucine is essential in humans, meaning the body cannot synthesize it, and must be ingested in our diet. Isoleucine is synthesized from pyruvate employing leucine biosynthesis enzymes in other organisms suc...
References:
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Underground isoleucine biosynthesis pathways in E. coli.
Elife. 2020 Aug 24;9:e54207. doi: 10.7554/eLife.54207. -
The genetic architecture of branched-chain amino acid accumulation in tomato fruits.
J Exp Bot. 2011 Jul;62(11):3895-906. doi: 10.1093/jxb/err091. Epub 2011 Mar 24. -
The amino acid valine is secreted in continuous-flow bacterial biofilms.
J Bacteriol. 2008 Jan;190(1):264-74. doi: 10.1128/JB.01405-07. Epub 2007 Nov 2. -
Changes in nonmyocyte tissue composition associated with pressure overload of hypertrophic human hearts.
Pathol Res Pract. 1989 Jun;184(6):577-81. doi: 10.1016/S0344-0338(89)80162-1.
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