Biosynthesis of Leucine

Description:

Isoleucine is essential amino acid, only synthesized in plants and bacteria, and required in the diet by animals. In proteins, the hydrophobic Isoleucine side-chain tends to reside with other hydrophobic residues in the interior of globular proteins or in transmembrane domains. Isoleucine biosynthesis begins with the common metabolic intermediate Pyruvate, the endpoint of glycolysis. The first step in Isoleucine biosynthesis requires TPP (Thiamine Pyrophosphate) to form a carbanion intermediate. This intermediate undergoes ...

References:

Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine.
Bareich D, Koteva K, Nazi I, Wright GD.
Bioorg Med Chem. 2004 Feb 15;12(4):807-15.
Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability. Biochemistry.
Amorim Franco TM, Blanchard JS.
2017 Nov 7;56(44):5849-5865.
The genetic architecture of branched-chain amino acid accumulation in tomato fruits.
Kochevenko A, Fernie AR.
J Exp Bot. 2011 Jul;62(11):3895-906.

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Pathways

Biosynthesis of Leucine

Description:

References:

Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine.

Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability. Biochemistry.

The genetic architecture of branched-chain amino acid accumulation in tomato fruits.

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Institutional License

Pathways

Biosynthesis of Leucine

Description:

References:

Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine.

Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability. Biochemistry.

The genetic architecture of branched-chain amino acid accumulation in tomato fruits.

Databases

Tools

Institutional License

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