The amino acid L-lysine is synthesized by plants and microorganisms by two different pathways, one proceeding via Diaminopimelate and the other via Alpha-Aminoadipate. Humans, however, cannot synthesise the compound and so it is an essential part of their diet. The Diaminopimelate pathway operates in bacteria, lower fungi and green plants. This pathway is the source of the lysine and Diaminopimelate incorporated into bacterial cell wall peptidoglycan and therefore there has been extensive investigation of its enzymes with a...
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