Pathways
Biosynthesis of Lysine
Description:
The amino acid L-lysine is synthesized by plants and microorganisms by two different pathways, one proceeding via Diaminopimelate and the other via Alpha-Aminoadipate. Humans, however, cannot synthesise the compound and so it is an essential part of their diet. The Diaminopimelate pathway operates in bacteria, lower fungi and green plants. This pathway is the source of the lysine and Diaminopimelate incorporated into bacterial cell wall peptidoglycan and therefore there has been extensive investigation of its enzymes with a...
References:
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Molecular evolution of the lysine biosynthetic pathways.
J Mol Evol. 2002 Oct;55(4):445-59. -
The fungal α-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.
Mol Microbiol. 2012 Dec;86(6):1508-30. -
Distribution of genes for lysine biosynthesis through the aminoadipate pathway among prokaryotic genomes.
Bioinformatics. 2001 Feb;17(2):189-91. -
Analysis and manipulation of aspartate pathway genes for L-lysine overproduction from methanol by Bacillus methanolicus.
Appl Environ Microbiol. 2011 Sep;77(17):6020-6.
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