Pathways
Biosynthesis of Melanin
Description:
Melanins are naturally occurring pigments found in plants as Allomelanin, whereas in animals as classes of natural Melanins as the black-brown Eumelanin found in human black hair and in the retina of the eye and the yellow-red Pheomelanin found in red hair and red feathers. Melanin in mammals protects the skin from damage caused by ultraviolet radiation, acts as free radical scavenger reducing the production of reactive oxygen species (ROS) generated within the cytoplasm (Ref.1&2). Keratinocytes, the outermost layer of...
References:
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Thiosemicarbazones with tyrosinase inhibitory activity.
Medchemcomm. 2019 Feb 5;10(3):378-389. doi: 10.1039/c9md00005d. eCollection 2019 Mar 1. Review. -
MC1R, eumelanin and pheomelanin: their role in determining the susceptibility to skin cancer.
Photochem Photobiol. 2015 Jan-Feb;91(1):188-200. doi: 10.1111/php.12335. Epub 2014 Nov 7. Review. -
Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.
J Enzyme Inhib Med Chem. 2017 Dec;32(1):403-425. doi: 10.1080/14756366.2016.1256882. Review. -
. Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase.
J Invest Dermatol. 2007 Apr;127(4):751-61. Epub 2007 Jan 11. Review.
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