Pathways
Biosynthesis of Neurotransmitters
Description:
For neuronal signal transduction, the presynaptic cell synthesizes neurotransmitters that then traverse the synaptic cleft. Neurotransmitters are signaling molecules used by neurons to communicate across chemical synapses. The receptors for neurotransmitters include GPCRs (G-Protein Coupled Receptors) and ligand-gated ion channels. The biogenic amines are neurotransmitters derived from amino acids, and include Dopamine, Epinephrine, GABA, Histamine and Serotonin. For each of these, decarboxylation of an amino acid is a key...
References:
-
Safety of 5-hydroxy-L-tryptophan.
Toxicol Lett. 2004 Apr 15;150(1):111-22. Review. -
Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles.
J Biomed Sci. 2003 Nov-Dec;10(6 Pt 2):774-81. -
Histamine production via mast cell-independent induction of histidine decarboxylase in response to lipopolysaccharide and interleukin-1.
Int Immunopharmacol. 2004 Apr;4(4):513-20. -
Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles.
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4293-8. Epub 2003 Mar 12.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions