Pathways
Biosynthesis of Plasmalogens
Description:
Plasmalogens are glycerophospholipids of neural membranes containing vinyl ether bonds. Their synthetic pathway is located in peroxisomes and endoplasmic reticulum. About 20% of mammalian Glycerophospholipids are Plasmalogens. The exact percentage varies both from species to species and from tissue to tissue within a given organisms. While Plamalogens comprise only 0.8% of phospholipids in human liver, they account for 23% of those in human nervous tissue (Ref.1).
One of the starting materials for...
References:
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Structural and functional roles of ether lipids
Protein Cell. 2018 Feb;9(2):196-206. Epub 2017 May 18. -
Studies of myo-inositol and plasmalogen metabolism in rat brain.
Neurochem Res. 2004 Apr;29(4):843-55. -
From peroxisomal disorders to common neurodegenerative diseases - the role of ether phospholipids in the nervous system.
FEBS Lett. 2017 Sep;591(18):2761-2788.
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