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Biosynthesis of Progesterone


Cholesterol is the common precursor of all steroid hormones and is biosynthesized in many tissues. Steroid hormones are characterized by a common basic structure of cyclopentane-perhydro-phenantrene, a polycyclic complex of 17 carbon atoms forming a four-ring system. Altering a side chain or subsistent group of a cholesterol molecule produces various steroids molecules.  Pregnenolone and progesterone are molecules derived from cholesterol (Ref.1&2).

Cholesterol is converted to pregnenolone inside the mitochondr...




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