Pathways
Biosynthesis of Proline
Description:
Proline is unique in having a cyclic structure with its side chain connected to the amino group to create a secondary amine. As a consequence of its cyclic structure, Proline constrains the structure of proteins where it occurs, disrupting Alpha-helices. Isomerization between the cis and trans forms of Proline in proteins is isomerized by peptidyl-prolyl isomerases like the cyclophilins that contribute to protein folding and are components of signal transduction pathways (Ref.1).
Proline is derive...
References:
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3-Substituted prolines: from synthesis to structural applications, from peptides to foldamers.
Molecules. 2013 Feb 19;18(2):2307-27. -
Pyrroline-5-carboxylate synthase and proline biosynthesis: from osmotolerance to rare metabolic disease.
Protein Sci. 2010 Mar;19(3):372-82. -
Evolution of proline biosynthesis: enzymology, bioinformatics, genetics, and transcriptional regulation.
Biol Rev Camb Philos Soc. 2015 Nov;90(4):1065-99.
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