Biosynthesis of Spermidine and Spermine

Description:

The polyamines Spermidine and Spermine are naturally occurring ubiquitous polycations involved in the regulation of cell growth, differentiation, apoptosis and progression through the cell cycle. (Ref.1). Cellular polyamine levels are regulated by multiple pathways such as synthesis from amino acid precursors, cellular uptake mechanisms that salvage polyamines from diet and intestinal microorganisms, as well as stepwise degradation and efflux (Ref.2).

Putrescine and S-Adenosylmethionine are t...

References:

Polyamine Function in Plants: Metabolism, Regulation on Development, and Roles in Abiotic Stress Responses.
Chen D, Shao Q, Yin L, Younis A, Zheng B.
Front Plant Sci. 2019 Jan 10;9:1945.
Polyamines and Gut Microbiota.
Tofalo R, Cocchi S, Suzzi G.
Front Nutr. 2019 Feb 25;6:16.
Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications.
Thomas T, Thomas TJ.
Cell Mol Life Sci. 2001 Feb;58(2):244-58.

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Pathways

Biosynthesis of Spermidine and Spermine

Description:

References:

Polyamine Function in Plants: Metabolism, Regulation on Development, and Roles in Abiotic Stress Responses.

Polyamines and Gut Microbiota.

Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications.

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Institutional License

Pathways

Biosynthesis of Spermidine and Spermine

Description:

References:

Polyamine Function in Plants: Metabolism, Regulation on Development, and Roles in Abiotic Stress Responses.

Polyamines and Gut Microbiota.

Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications.

Databases

Tools

Institutional License

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