Pathways
Biosynthesis of Sphingolipids
Description:
Sphingolipids structural components of the cell membrane play a key role in the regulation of several cellular processes. Cell signaling related to sphingolipids induces apoptosis, cell cycle arrest and cell growth. There are multiple bioactive sphingolipids metabolites which include ceramide, sphingosine-1-phosphate, sphingosine, and sphingomyelin which may act as secondary messengers in cellular signal transduction pathways. Sphingolipids are abundant components of the myelin sheath which protects and insulates cells of ...
References:
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Sphingolipid metabolic pathway: an overview of major roles played in human diseases.
J Lipids. 2013;2013:178910. doi: 10.1155/2013/178910. Epub 2013 Aug 4. -
Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies.
Cell Death Discov. 2018 Jun 28;4:4. doi: 10.1038/s41420-018-0075-0. eCollection 2018. Erratum in: Cell Death Discov. 2019 Jul 10;5:116. -
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors.
Biochim Biophys Acta. 2013 Jan;1831(1):157-66. doi: 10.1016/j.bbalip.2012.07.002. Epub 2012 Jul 16. Review. -
An overview of sphingolipid metabolism: from synthesis to breakdown.
Adv Exp Med Biol. 2010;688:1-23. Review.
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