Pathways
Biotin Biosynthesis in B. sphaericus
Description:
Biotin (Vitamin-H) is essential for all living organisms and acts as a cofactor for a few essential enzymes of the Carboxylase family. Higher plants, most fungi and bacteria, are prototrophic for Biotin. Others, including most vertebrates and some bacteria, rely on exogenous sources. In mammals, Biotin is supplied by intestinal bacteria. Biotin is a colorless Vitamin and Orthorhombic when crystallized. It consists of two fused rings: an Imidazol (Ureido) and a Sulfur-containing (Tetrahydrothiophene) ring; and the latter is ex...
References:
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A Canonical Biotin Synthesis Enzyme, 8-Amino-7-Oxononanoate Synthase (BioF), Utilizes Different Acyl Chain Donors in Bacillus subtilis and Escherichia coli.
Appl Environ Microbiol. 2017 Dec 15;84(1):e02084-17. doi: 10.1128/AEM.02084-17. -
Mechanisms of biotin-regulated gene expression in microbes.
Synth Syst Biotechnol. 2016 Feb 5;1(1):17-24. doi: 10.1016/j.synbio.2016.01.005. -
A complex between biotin synthase and the iron-sulfur cluster assembly chaperone HscA that enhances in vivo cluster assembly.
Biochemistry. 2009 Nov 17;48(45):10782-92. doi: 10.1021/bi901393t.
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