Pathways
Biotin Metabolism in S. cerevisiae
Description:
In unicellular eukaryotes like S. cerevisiae (Saccharomyces cerevisiae), Biotin or Vitamin-H, a member of B-Complex group of Vitamins acts as a cofactor for a few essential enzymes of the Carboxylase family. It is also required for the biosynthesis of fatty acids and the metabolism of amino acids and carbohydrates. Some organisms, including higher plants and most fungi and bacteria, are prototrophic for Biotin. Others, including most vertebrates and some bacteria, rely on exogenous sources (Ref.1 &...
References:
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The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering.
Genetics. 2007 Dec;177(4):2293-307. doi: 10.1534/genetics.107.074963. -
Laboratory Evolution of a Biotin-Requiring Saccharomyces cerevisiae Strain for Full Biotin Prototrophy and Identification of Causal Mutations.
Appl Environ Microbiol. 2017 Aug 1;83(16):e00892-17. doi: 10.1128/AEM.00892-17. -
Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation.
EcoSal Plus. 2014 May;6(1):10.1128/ecosalplus.ESP-0001-2012. doi: 10.1128/ecosalplus.ESP-0001-2012.
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