Pathways
Biotin Metabolism in H. sapiens
Description:
Biotin or Vitamin-H, an essential micronutrient for all mammals belongs to the B-Complex group of Vitamins. It is a water-soluble Vitamin used as co-factor of Biotin-dependent Carboxylases. The role of Biotin in Carboxylases is to act as vector for carboxyl-group transfer between donor and acceptor molecules during Carboxylation reaction (Ref.1). In H. sapiens (Homo sapiens), Biotin is a covalently bound as a prosthetic group for five Biotin-dependent Carboxylases namely PCC (Propionyl-CoA Carboxylase) group; PC (Pyruvat...
References:
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B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review.
Nutrients. 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. Review. -
Selectivity in post-translational biotin addition to five human carboxylases.
J Biol Chem. 2012 Jan 13;287(3):1813-22. doi: 10.1074/jbc.M111.275982. Epub 2011 Nov 28. -
Biotin in metabolism and molecular biology.
Annu. Rev. Nutr. 2002;22:221-39. -
Biotin thiamine responsive basal ganglia disease-A potentially treatable inborn error of metabolism.
Neurol India. 2016 Nov-Dec;64(6):1328-1331. doi: 10.4103/0028-3886.193797. No abstract available.
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