Pathways
Biotin Metabolism in B. subtilis
Description:
The colorless and orthorhombic Vitamin, Biotin or Vitamin-H, is essential for all living organisms and acts as a cofactor for a few essential enzymes of the Carboxylase family. Bacteria, most fungi and higher plants, are prototrophic for Biotin. Most vertebrates and even some bacteria, rely on exogenous sources. In mammals, Biotin is supplied by intestinal bacteria. In general, Biotin consists of two fused rings: an Imidazol (Ureido) and a Sulfur-containing (Tetrahydrothiophene) ring; and the latter being extended via a Valer...
References:
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A Canonical Biotin Synthesis Enzyme, 8-Amino-7-Oxononanoate Synthase (BioF), Utilizes Different Acyl Chain Donors in Bacillus subtilis and Escherichia coli.
Appl Environ Microbiol. 2017 Dec 15;84(1):e02084-17. doi: 10.1128/AEM.02084-17. -
Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis.
J. Biol. Inorg. Chem. 2001 Jun;6(5-6):523-33. -
Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis.
Mol Microbiol. 2017 May;104(4):595-607. doi: 10.1111/mmi.13648. Epub 2017 Mar 3. -
Engineering of a Bacillus subtilis strain with adjustable levels of intracellular biotin for secretory production of functional streptavidin.
Appl. Environ. Microbiol. 2002 Mar;68(3):1102-8.
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