Coagulation is a dynamic process which involves the regulated sequence of proteolytic activation of a series of zymogens to achieve appropriate and timely haemostasis in an injured vessel, in an environment that overwhelmingly favours an anticoagulant state [Ref.1 & 2]. There are two main mechanisms for triggering the blood clotting, termed as the contact pathway/intrinsic pathway and the tissue factor pathway/extrinsic pathway [Ref.3].
The contact pathway of coagulation is initiated by activation of factor XII (fXII) in ...
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