Pathways
BMP Pathway
Description:
BMPs (Bone morphogenetic proteins) are the members of the transforming growth factor-beta superfamily of secreted signaling molecules [Ref.1]. Transduction of BMP signal involves two types of transmembrane serine/threonine kinase receptors: type I and type II [Ref.1]. BMP2, BMP4, BMP5,BMP6, BMP7, BMP8, BMP9, BMP10, BMP12, BMP13 and BMP14 (Bone morphogenetic protein 2, 4, 5, 6 ,7, 8, 9, 10, 12, 13 and 14) can bind to three type I receptors: BMPR1A (Bone morphogenetic protein receptor, type IA), BMPR1B (Bone morphogenetic prote...
References:
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TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation.
Bone Res. 2015 Apr 14; 3:15005. doi: 10.1038/boneres.2015.5. eCollection 2015. Review. -
BMP signaling in vascular diseases.
FEBS Lett. 2012 Jul 4; 586(14):1993-2002. doi: 10.1016/j.febslet.2012.04.030. Epub 2012 May 3. Review. -
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease.
Bone Res. 2016 Apr 26; 4:16009. doi: 10.1038/boneres.2016.9. eCollection 2016. Review. -
Bone Morphogenetic Protein (BMP) signaling in development and human diseases.
Genes Dis. 2014 Sep; 1(1):87-105.
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