Pathways
BRCA1 Pathway
Description:
BRCA1(Breast Cancer Susceptibility Protein-1) is a versatile protein that links DNA damage sensing and DDR effectors. BRCA1 interacts with tumour suppressors, DNA repair proteins and cell cycle regulators through its various functional domains and thereby has diverse roles in multiple DNA repair pathways (particularly HR, NHEJ and SSA (single-strand annealing)) and in checkpoint regulation. BRCA1 contains an amino-terminal RING domain that has E3 ubiquitin ligase activity (which catalyses protein ubiquitylation) and a BRCT(BR...
References:
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BRCA1 and BRCA2: different roles in a common pathway of genome protection.
Nat Rev Cancer. 2011 Dec 23;12(1):68-78. doi: 10.1038/nrc3181. Review. -
BRCA1, a 'complex' protein involved in the maintenance of genomic stability.
FEBS J. 2015 Feb;282(4):630-46. doi: 10.1111/febs.13150. Epub 2014 Dec 2. Review. -
BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions.
Mol Cancer Ther. 2006 Jun;5(6):1396-404. Review. -
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
J Biol Chem. 2012 Jan 27;287(5):3366-80. doi: 10.1074/jbc.M111.311241. Epub 2011 Dec 13.
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