Pathways
Breast Cancer Regulation by Stathmin1
Description:
Stmn1 (Stathmin-1) also referred to as Op18 (Oncoprotein-18) is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly expressed in a wide variety of cancers and its high abundance seems to be necessary for the maintenance of the transformed phenotypes. Breast cancers exhibit high levels of Stmn1 and may be resistant to anti-microtubule agents. Stmn1 destabilizes microtubule polymers of Alpha and Beta-Tubulin subunits, by promoting catastrophes that u...
References:
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Stathmin-dependent molecular targeting therapy for malignant tumor: the latest 5 years' discoveries and developments.
J Transl Med. 2016 Sep 27;14(1):279. Review. -
Stathmin regulates centrosomal nucleation of microtubules and tubulin dimer/polymer partitioning.
MolBiol Cell. 2009 Aug;20(15):3451-8. doi: 10.1091/mbc.E09-02-0140. Epub 2009 Jun 10. -
Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?
Nat. Rev. Cancer. 2004 Dec;4(12):948-55. -
Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas.
Oncogene. 2002 Jul 18;21(31):4830-7.
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