Pathways
Calcium Mediated T-Cell Apoptosis
Description:
Ca2+ (Calcium) plays a major role in life and death within T-Cells. Elevation of intracellular free Ca2+ is one of the key triggering signals for T-Cell activation by antigen. The binding of antigen, MHC Class-II (Major Histocompatibility Complex Class-II), to the TCR-CD3 (T-Cell Antigen Receptor)-CD3 (CD3 Antigen) triggers the recruitment of a series of tyrosine kinases and substrates to the TCR/CD3/CD4 (CD4 Antigen) Complex, ultimately resulting in the phosphorylation and activation of PLC-Gamma1 (Phospholipase-C-Gamma1). PLC-...
References:
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Modulation of T Cell Metabolism and Function through Calcium Signaling.
Front Immunol. 2013 Oct 11;4:324. doi: 10.3389/fimmu.2013.00324. Review. -
Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.
Mol Cell. 2017 Jun 15;66(6):780-788. doi: 10.1016/j.molcel.2017.05.028. Review. -
Spatially restricted subcellular Ca2+ signaling downstream of store-operated calcium entry encoded by a cortical tunneling mechanism.
Sci Rep. 2018 Jul 25;8(1):11214. doi: 10.1038/s41598-018-29562-9. -
Calcium influx through TRP channels induced by short-lived reactive species in plasma-irradiated solution.
Sci Rep. 2016 May 12;6:25728. doi: 10.1038/srep25728.
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