Pathways
Calpain Protease Regulates Cellular Mechanics
Description:
Calpain is an evolutionary old family of soluble, neutral, calcium-dependent proteases, which have the unique property of using protein cleavage to modify the activity/function of their substrate proteins. There are two major calpain isoforms in the brain, calpain-1 and calpain-2. Calpain-1 and Calpain-2 exhibit opposite functions in both synaptic plasticity and neurodegeneration. Calpain-1 activation is required for the induction of long-term potentiation (LTP) and is generally neuroprotective, while calpain-2 activation lim...
References:
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Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration.
Trends Neurosci. 2016 Apr; 39(4):235-245. doi: 10.1016/j.tins.2016.01.007. Epub 2016 Feb 10. Review. -
Calpains: Master Regulators of Synaptic Plasticity.
Neuroscientist. 2016 May 17. pii: 1073858416649178. [Epub ahead of print] Review. -
v-Src's hold over actin and cell adhesions.
Nat Rev Mol Cell Biol. 2002 Apr; 3(4):233-45. Review. -
Regulating cell migration: calpains make the cut.
J Cell Sci. 2005 Sep 1; 118(Pt 17):3829-38. Review.
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