cAMP Signaling in C. neoformans

Description:

C. neoformans (Cryptococcus neoformans) is an encapsulated yeast-like basidiomycetous fungus and a significant human pathogen responsible for fungal meningoencephalitis in immune-compromised individuals. It has emerged as a model organism to study the molecular mechanisms of fungal pathogenesis (Ref.1). Desiccated yeast cells or basidiophores of C. neoformans when inhaled can stay in the alveoli of the host causing primary lung infection. On crossing the blood–brain barrier (BBB), these ...

References:

Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans.
Ero R, Dimitrova VT, Chen Y, Bu W, Feng S, Liu T, Wang P, Xue C, Tan SM, Gao YG.
Sci Rep. 2015 Mar 3;5:8688. doi: 10.1038/srep08688.
Environmental Factors That Contribute to the Maintenance of Cryptococcus neoformans Pathogenesis.
Maliehe M, Ntoi MA, Lahiri S, Folorunso OS, Ogundeji AO, Pohl CH, Sebolai OM.
Microorganisms. 2020 Jan 28;8(2):180. doi: 10.3390/microorganisms.
The Stress-Activated Signaling (SAS) Pathways of a Human Fungal Pathogen, Cryptococcus neoformans.
Jung KW, Bahn YS.
Mycobiology. 2009 Sep;37(3):161-70. doi: 10.4489/MYCO.2009.37.3.161. Epub 2009 Sep 30.
Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A.
Geddes JM, Croll D, Caza M, Stoynov N, Foster LJ, Kronstad JW.
BMC Microbiol. 2015 Oct 9;15:206. doi: 10.1186/s12866-015-0532-3.

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Pathways

cAMP Signaling in C. neoformans

Description:

References:

Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans.

Environmental Factors That Contribute to the Maintenance of Cryptococcus neoformans Pathogenesis.

The Stress-Activated Signaling (SAS) Pathways of a Human Fungal Pathogen, Cryptococcus neoformans.

Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A.

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Institutional License

Pathways

cAMP Signaling in C. neoformans

Description:

References:

Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans.

Environmental Factors That Contribute to the Maintenance of Cryptococcus neoformans Pathogenesis.

The Stress-Activated Signaling (SAS) Pathways of a Human Fungal Pathogen, Cryptococcus neoformans.

Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A.

Databases

Tools

Institutional License

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