Pathways
Cancer Elimination
Description:
The immune system has three primary roles in the prevention of tumors. First, the immune system can protect the host from virus-induced tumors by eliminating or suppressing viral infections. Second, the timely elimination of pathogens and prompt resolution of inflammation can prevent the establishment of an inflammatory environment conducive to tumorigenesis. Third, the immune system can specifically identify and eliminate tumor cells on the basis of their expression of tumor-specific antigens or molecules induced by cellular...
References:
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Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity.
Adv Immunol. 2006;90:1-50. Review. -
Immune surveillance of tumors.
J Clin Invest. 2007 May;117(5):1137-46. Review. -
New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escape.
Curr Opin Immunol. 2014 Apr;27:16-25. doi: 10.1016/j.coi.2014.01.004. Epub 2014 Feb 14. Review. -
Cancer as an immune-mediated disease.
Immunotargets Ther. 2012 Jun 13;1:1-6. doi: 10.2147/ITT.S29834. eCollection 2012.
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