Pathways
Cancer Recognition
Description:
Cancer immunotherapy attempts to exploit the exquisite power and specificity of the immune system for the treatment of malignancy. Although cancer cells are less immunogenic than pathogens, the immune system is clearly capable of recognizing and eliminating tumour cells. However, tumors frequently interfere with the development and function of immune responses. Thus, the challenge for immunotherapy is to use advances in cellular and molecular immunology to develop strategies that effectively and safely augment antitumour resp...
References:
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Cancer Immunotherapy, Part 1: Current Strategies and Agents.
P T. 2017 Jun;42(6):375-383. -
Harnessing the immune system to improve cancer therapy.
Ann Transl Med. 2016 Jul;4(14):261. doi: 10.21037/atm.2016.04.01. Review. -
Effect of NKG2D ligand expression on host immune responses.
Immunol Rev. 2010 May;235(1):267-85. doi: 10.1111/j.0105-2896.2010.00893.x. Review. -
Natural innate and adaptive immunity to cancer.
Annu Rev Immunol. 2011;29:235-71. doi: 10.1146/annurev-immunol-031210-101324. Review.
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