Pathways
Cardiolipin Synthesis in S. cerevisiae
Description:
CL (Cardiolipin/Diphosphatidylglycerol) is a unique Phospholipid carrying four acyl groups and two negative charges. Chemically it is known as 1,3-bis (1',2'-diacyl-3'-phosphoryl-sn-glycerol)-sn-glycerol). CL is ubiquitous in eukaryotes and is required for activity of several mitochondrial enzymes and protein import. After the conversion of PA (Phosphatidate/Phosphatidic Acid) plus CTP (Cytidine Triphosphate) to CDP-DAG (Cytidine Diphosphate-Diacylglycerol) and pyrophosphate by CDS1 (CDP-DAG Synthase), CL biosynth...
References:
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The topology and regulation of cardiolipin biosynthesis and remodeling in yeast.
Chem Phys Lipids. 2014 Apr;179:25-31. doi: 10.1016/j.chemphyslip.2013.10.008. Epub 2013 Nov 1. -
Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae.
Sci Rep. 2017 Nov 27;7(1):16447. doi: 10.1038/s41598-017-16661-2. -
Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases.
Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8687-92. doi: 10.1073/pnas.1608396113. Epub 2016 Jul 5.
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