Cardiomyocyte Differentiation through BMP Receptors

Description:

BMP (Bone Morphogenetic Protein) Receptors are essential, beyond the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis. ALK3 (Activin Receptor-Like Kinase-3) is specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum and endocardial cushion. The invariable defects in myocardium results from congenital deletion of ALK3 and this provide strong support for its assessment as a candidate gene in human congenital heart diseas...

References:

Bone Morphogenetic Protein (BMP) signaling in development and human diseases.
Wang RN, Green J, Wang Z, Deng Y, Qiao M, Peabody M, Zhang Q, Ye J, Yan Z, Denduluri S, Idowu O, Li M, Shen C, Hu A, Haydon RC, Kang R, Mok J, Lee MJ, Luu HL, Shi LL.
Genes Dis. 2014 Sep;1(1):87-105.
BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks.
Beets K, Staring MW, Criem N, Maas E, Schellinx N, de Sousa Lopes SM, Umans L, Zwijsen A.
BMC Dev Biol. 2016 Oct 10;16(1):34.
Regulation of fetal gene expression in heart failure.
Dirkx E, da Costa Martins PA, De Windt LJ.
Biochim Biophys Acta. 2013 Dec;1832(12):2414-24. doi: 10.1016/j.bbadis.2013.07.023. Epub 2013 Sep 10. Review.
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease.
Wu M, Chen G, Li YP.
Bone Res. 2016 Apr 26;4:16009. doi: 10.1038/boneres.2016.9. eCollection 2016. Review.

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Cardiomyocyte Differentiation through BMP Receptors

Description:

References:

Bone Morphogenetic Protein (BMP) signaling in development and human diseases.

BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks.

Regulation of fetal gene expression in heart failure.

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease.

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Tools

Institutional License

Pathways

Cardiomyocyte Differentiation through BMP Receptors

Description:

References:

Bone Morphogenetic Protein (BMP) signaling in development and human diseases.

BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks.

Regulation of fetal gene expression in heart failure.

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease.

Databases

Tools

Institutional License

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