Pathways
Caspase Cascade
Description:
Caspases are a family of evolutionary conserved cysteine dependent aspartate-specific proteases that play crucial roles in maintaining organismal homoeostasis throughout life.Mammalian caspases are broadly classified as being inflammatory/pyroptotic (human caspase-1, 4, 5 and 12, murine caspase-1, 11 and 12), or as initiators (human and murine caspase-2, 8, 9 and human caspase-10) and executioners (human and murine caspase-3, 6 and 7) of apoptotic cell death.The culmination of this cascade is the cleavage of a number of proteins...
References:
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Caspases in metabolic disease and their therapeutic potential.
Cell Death Differ. 2018 Jun;25(6):1010-1024. doi: 10.1038/s41418-018-0111-x. Epub 2018 May 9. -
Cellular mechanisms controlling caspase activation and function.
Cold Spring Harb Perspect Biol. 2013 Jun 1;5(6). pii: a008672. doi: 10.1101/cshperspect.a008672. Review. -
TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.
Cell Signal. 2013 Aug;25(8):1654-64. doi: 10.1016/j.cellsig.2013.04.005. Epub 2013 Apr 21. Review. -
Human Granzyme B Based Targeted Cytolytic Fusion Proteins.
Biomedicines. 2018 Jun 20;6(2). pii: E72. doi: 10.3390/biomedicines6020072. Review.
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