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Catabolic Pathway for Arginine, Histidine, Glutamate, Glutamine and Proline


Arginine serves as a precursor for synthesis of protein, nitric oxide, creatine, polyamines, agmatine, and urea. It is synthesized from glutamine, glutamate, and proline and is metabolically interconvertible with the amino acids proline and glutamate. ARG1 (arginase 1) converts L-arginine into L-ornithine and urea. L-ornithine is acted upon by OAT (ornithine aminotransferase) to further synthesize L-glutamate-5-semialdehyde which spontaneously undergoes non-enzymatic reactio...




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