Catabolic Pathway for Asparagine and Aspartate

Description:

Asparagine, a non essential amino acid, synthesized form oxaloacetic acid. It is an amide of a amino acid Aspartate. The enzymes ASPG (asparaginase) and ASRGL1 (asparaginase and isoaspartyl peptidase 1) catalyze the hydrolysis of Asparagine to Aspartate and Ammonia. The enzyme GOT1 (glutamic-oxaloacetic transaminase 1) catalyzes the transamination of Aspartate to oxaloacetic acid which can su...

References:

Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.
Nomme J, Su Y, Konrad M, Lavie A.
Biochemistry. 2012 Aug 28;51(34):6816-26. Epub 2012 Aug 14
Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients.
D'Aniello A, Fisher G, Migliaccio N, Cammisa G, D'Aniello E, Spinelli P.
Neurosci Lett. 2005 Nov 4;388(1):49-53.
Asparagine synthetase: Function, structure, and role in disease.
Lomelino CL, Andring JT, McKenna R, Kilberg MS.
J Biol Chem. 2017 Dec 8;292(49):19952-19958. doi: 10.1074/jbc.R117.819060. Epub 2017 Oct 30. Review.
Asparagine synthetase: regulation by cell stress and involvement in tumor biology.
Balasubramanian MN, Butterworth EA, Kilberg MS.
Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E789-99. doi: 10.1152/ajpendo.00015.2013. Epub 2013 Feb 12. Review.

You can view details of this pathway by subscribing:

Subscribe Now

Pathways

Catabolic Pathway for Asparagine and Aspartate

Description:

References:

Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.

Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients.

Asparagine synthetase: Function, structure, and role in disease.

Asparagine synthetase: regulation by cell stress and involvement in tumor biology.

Databases

Tools

Institutional License

Pathways

Catabolic Pathway for Asparagine and Aspartate

Description:

References:

Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.

Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients.

Asparagine synthetase: Function, structure, and role in disease.

Asparagine synthetase: regulation by cell stress and involvement in tumor biology.

Databases

Tools

Institutional License

Log In