Pathways
Catabolic Pathways for Alanine, Glycine, Serine, Cysteine, Tryptophan and Threonine
Description:
Five amino acids, Alanine, Cysteine, Glycine, Serine and Threonine are broken down to yield Pyruvate. Tryptophan is included in this group since one of its breakdown products is Alanine, which is transaminated to Pyruvate. Alanine is an important in inter tissue nitrogen transporter and is an important part of the Glucose-Alanine cycle. The alanine catabolic pathway involves a simple aminotransferase reaction that directly produces pyruvate. The transamination is carried out by GPT
You can view details of this pathway by subscribing:References:
Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing.
Nat Commun. 2019 Jul 25;10(1):3325. doi: 10.1038/s41467-019-11129-5.
Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells.
Life Sci Alliance. 2018 May 21;1(2):e201800036. doi: 10.26508/lsa.201800036. eCollection 2018 May.
The importance of serine metabolism in cancer.
J Cell Biol. 2016 Aug 1;214(3):249-57. doi: 10.1083/jcb.201604085. Epub 2016 Jul 25. Review.
Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology.
J Pathol. 2016 Jan;238(2):321-32. doi: 10.1002/path.4659. Epub 2015 Nov 13. Review.
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