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Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine


The carbon skeletons of Methionine, Isoleucine, Threonine and Valine are degraded by pathways that yield Succinyl-CoA (Succinyl-Coenzyme A), an intermediate of the Citric Acid Cycle. Methionine donates its Methyl group to one of several possible acceptors through S-adenosylmethionine and three of its four remaining carbon atoms are converted to the Propionate of Propionyl-CoA, a precursor of Succinyl-CoA. Isoleucine undergoes transamination, followed by oxidative decarboxylation of the resulting Alpha-Keto Acid. The rema...




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