Pathways
Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine
Description:
The carbon skeletons of Methionine, Isoleucine, Threonine and Valine are degraded by pathways that yield Succinyl-CoA (Succinyl-Coenzyme A), an intermediate of the Citric Acid Cycle. Methionine donates its Methyl group to one of several possible acceptors through S-adenosylmethionine and three of its four remaining carbon atoms are converted to the Propionate of Propionyl-CoA, a precursor of Succinyl-CoA. Isoleucine undergoes transamination, followed by oxidative decarboxylation of the resulting Alpha-Keto Acid. The rema...
References:
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Reconstruction of pathways associated with amino acid metabolism in human mitochondria.
Genomics Proteomics Bioinformatics. 2007 Dec;5(3-4):166-76. doi: 10.1016/S1672-0229(08)60004-2. -
The Effect of 2-Ketobutyrate on Mitochondrial Substrate-Level Phosphorylation.
Neurochem Res. 2019 Oct;44(10):2301-2306. doi: 10.1007/s11064-019-02759-8. Epub 2019 Feb 27. -
Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes.
PLoS One. 2015 Dec 28;10(12):e0145850. doi: 10.1371/journal.pone.0145850. eCollection 2015. -
Disorders of branched chain amino acid metabolism.
Transl Sci Rare Dis. 2016 Nov 7;1(2):91-110. doi: 10.3233/TRD-160009.
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