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CCKBR-Gastrin Stimulated Signaling


Gastrin is the primary hormone that induces gastric acid secretion. In humans, the gene encoding for gastrin is located on chromosome 17q21. This hormone is produced by the G-cells of the antrum of stomach as preprogastrin, which comprises of 101 amino acids and is cleaved between Ala-21 and Ser-22 to yield progastrin.Gastrin interacts with the membrane-bound G-protein coupled cholecystokinin receptor group consisting of CCKAR(Cho[...]




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