Pathways
CCR3 Pathway in Eosinophils
Description:
Human eosinophils are crucial effector cells implicated in a number of chronic inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases, and parasitic infections.The chemotactic response of eosinophils is mostly mediated by CCR3 (CC Chemokine Receptor-3), a member of the G protein-coupled, seven-transmembrane receptor family, linked to heterotrimeric G-Proteins. Although its expression was first thought to be limited to eosinophils, CCR3 is now known to be more widely expressed on cells involve...
References:
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Functional expression of CCL8 and its interaction with chemokine receptor CCR3.
BMC Immunol. 2017 Dec 28;18(1):54. doi: 10.1186/s12865-017-0237-5. -
What can we learn from molecular dynamics simulations for GPCR drug design?
Comput Struct Biotechnol J. 2014 Dec 10;13:111-21. doi: 10.1016/j.csbj.2014.12.002. eCollection 2015. -
Transcriptional Changes of Blood Eosinophils After Methacholine Inhalation Challenge in Asthmatics.
Genomics Insights. 2012 Jan 30;5:1-12. doi: 10.4137/GEI.S9125. eCollection 2012. -
PI3K, ERK, p38 MAPK and integrins regulate CCR3-mediated secretion of mouse and human eosinophil-associated RNases.
Allergy. 2013 Jul;68(7):880-9. doi: 10.1111/all.12163. Epub 2013 Jun 6.
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