CD40 Signaling

Description:

CD40, a TNFR (Tumor Necrosis Factor Receptor) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell death. First identified and functionally characterized on B-Cells, CD40 is expressed on a plethora of different cell types, including B-Cells, macrophages, dendritic cells, endothelial cells, and fibroblasts, and this widespread expression accounts for the central role of CD40 in the regulation of immune response and host defense (Ref.1)....

References:

Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer.
Lee HW, Choi HY, Joo KM, Nam DH.
Int J Mol Sci. 2015 Feb 25;16(3):4471-91. doi: 10.3390/ijms16034471. Review.
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE.
J Biol Chem. 2000 Jun 16;275(24):18586-93.
Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.
Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni PA, Shimoda M.
J Immunol. 2010 Jul 1;185(1):220-30. doi: 10.4049/jimmunol.0901689. Epub 2010 May 26. Erratum in: J Immunol. 2010 Aug 15;185(4):2631.
CD40 and CD40L in cell-mediated immunity.
Grewal IS, Flavell RA.
Annu Rev Immunol. 1998;16:111-35. Review.

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Pathways

CD40 Signaling

Description:

References:

Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer.

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.

CD40 and CD40L in cell-mediated immunity.

Databases

Tools

Institutional License

Pathways

CD40 Signaling

Description:

References:

Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer.

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.

CD40 and CD40L in cell-mediated immunity.

Databases

Tools

Institutional License

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