Pathways
CDC42 Pathway
Description:
Dynamic regulation of the actin cytoskeleton underpins a multitude of cellular processes, from cell movement and polarization1,2 to cell division.3 The actin cytoskeleton and the proteins involved in its regulation are also fundamentally linked to endocytosis and membrane trafficking.4,5 Members of the Rho family of small GTPases have emerged as important overseers of the actin cytoskeleton and a number of Rho family members and their downstream effector proteins have been linked to specific actin pathways. Among the Rho family ...
References:
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Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover.
Small GTPases. 2017 Oct 2;8(4):237-244. doi: 10.1080/21541248.2016.1215657. Epub 2016 Aug 11. Review. -
I'm coming to GEF you: Regulation of RhoGEFs during cell migration.
Cell Adh Migr. 2014;8(6):535-49. doi: 10.4161/cam.28721. Epub 2014 Oct 31. Review. -
Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function.
Molecules. 2017 Jul 24;22(7). pii: E1239. doi: 10.3390/molecules22071239. Review. -
Signaling networks of Rho GTPases in cell motility.
Cell Signal. 2013 Oct;25(10):1955-61. doi: 10.1016/j.cellsig.2013.04.009. Epub 2013 May 11. Review.
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