Pathways
CDC42 Signaling in S. cerevisiae
Description:
The S. cerevisiae (Saccharomyces cerevisiae) CDC42 (Cell Division Control Protein-42), a member of the Rho/Rac subfamily of Ras-Like GTPases (GTP-Binding Proteins) and Ras superfamily of low molecular-weight GTPases, is essential for the control of cell polarity during the yeast cell cycle. CDC42 occurs in both soluble and particulate pools, and neither its abundance nor its distribution varied through the cell cycle. In S. cerevisiae, CDC42 is localized to the bud site early in the cell cycle and this localization is critica...
References:
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The final cut: cell polarity meets cytokinesis at the bud neck in S. cerevisiae
Cell Mol Life Sci. 2016 Aug;73(16):3115-36. doi: 10.1007/s00018-016-2220-3. Epub 2016 Apr 16. -
Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae.
Small GTPases. 2020 Nov;11(6):430-440. doi: 10.1080/21541248.2018.1495008. Epub 2018 Jul 29. -
Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast.
Cell Cycle. 2020 Jul;19(14):1707-1715. doi: 10.1080/15384101.2020.1779469. Epub 2020 Jun 18. -
Regulation of Cdc42 for polarized growth in budding yeast.
Microb Cell. 2020 May 19;7(7):175-189. doi: 10.15698/mic2020.07.722.
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