Pathways
CDK5 Pathway
Description:
CDKs (Cyclin-dependent kinases) are a group of serine/threonine protein kinases activated by binding to a regulatory subunit cyclin.CDK5(Cyclin dependent kinase-5), a family member of the cyclin-dependent kinases, plays a pivotal role in the central nervous system. During embryogenesis, CDK5 is indispensable for brain development and, in the adult brain, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation. However, CDK5 activity becomes deregulated in severa...
References:
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Cdk5 activity in the brain - multiple paths of regulation.
J Cell Sci. 2014 Jun 1;127(Pt 11):2391-400. doi: 10.1242/jcs.147553. Review. -
Biological functions of CDK5 and potential CDK5 targeted clinical treatments.
Oncotarget. 2017 Mar 7;8(10):17373-17382. doi: 10.18632/oncotarget.14538. Review. -
A decade of CDK5.
Nat Rev Mol Cell Biol. 2001 Oct; 2(10):749-59. -
Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis?
Cell Signal. 2006 Aug;18(8):1101-7. Epub 2006 Mar 3. Review.
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