Cell Cycle Control by BTG Proteins

Description:

BTG2 (BTG Family Member-2) is endowed with antiproliferative activity. The expression of BTG2 in cycling cells induces accumulation of hypophosphorylated, growth-inhibitory forms of Rb (Retinoblastoma) and led to G1 arrest through impairment of DNA synthesis. Overexpression of CcnD1 (Cyclin-D1) counteracts G1 arrest. Rb is a nuclear phosphoprotein whose phosphorylation state oscillates regularly during the cell cycle. Its under-phosphorylated forms predominate in G0 and G1, while highly phosphorylated forms exist in S, G2 and...

References:

WX..BTG2 inhibits the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Li YJ, Dong BK, Fan M, Jiang
Int J ClinExpPathol. 2015 Oct 1;8(10):12410-8. eCollection 2015.
Molecular mechanisms underlying RB protein function.
Dick FA, Rubin SM.
Nat Rev Mol Cell Biol. 2013 May;14(5):297-306. doi: 10.1038/nrm3567. Epub 2013 Apr 18. Review.
HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progressionand Cyclin D1 Expression.
Micheli L, D'Andrea G, Leonardi L, Tirone F.
J Cell Physiol. 2017 Jul;232(7):1696-1707. doi: 10.1002/jcp.25467. Epub 2017 Jan 27.
Protein methylation and interaction with the antiproliferative gene, BTG2/TIS21/Pc3.
Paik WK, Kim S, Lim IK.
Yonsei Med J. 2014 Mar;55(2):292-303. doi: 10.3349/ymj.2014.55.2.292.

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Pathways

Cell Cycle Control by BTG Proteins

Description:

References:

WX..BTG2 inhibits the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/AKT pathway.

Molecular mechanisms underlying RB protein function.

HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progressionand Cyclin D1 Expression.

Protein methylation and interaction with the antiproliferative gene, BTG2/TIS21/Pc3.

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Cell Cycle Control by BTG Proteins

Description:

References:

WX..BTG2 inhibits the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/AKT pathway.

Molecular mechanisms underlying RB protein function.

HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progressionand Cyclin D1 Expression.

Protein methylation and interaction with the antiproliferative gene, BTG2/TIS21/Pc3.

Databases

Tools

Institutional License

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