Pathways
B-Cell Development
Description:
B lymphoid cells are essential for the humoral immune response by producing a diverse range of antigen-specific antibodies. Antibody-mediated immunity is provided by two distinctive B cell lineages that diverge early in life. The better-known conventional, or B2, B cells provide adaptive immunity by producing high-affinity pathogen-specific antibodies, typically in a T cell-dependent manner. The pool of B2 cells is constantly replenished from hematopoietic stem and progenitor cells in the bone marrow [Ref.1]. B1a cells provid...
References:
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B lymphocytes: how they develop and function
Blood. 2008 Sep 1; 112(5):1570-80. doi: 10.1182/blood-2008-02-078071. Review. -
B-1 B cell development in the fetus and adult.
Immunity. 2012 Jan 27; 36(1):13-21. doi: 10.1016/j.immuni.2011.11.017. Review. -
B-cell biology and development
J Allergy Clin Immunol. 2013 Apr; 131(4):959-71. doi: 10.1016/j.jaci.2013.01.046. Epub 2013 Mar 5. Review. -
Checkpoints that control B cell development.
J Clin Invest. 2015 Jun; 125(6):2203-10. doi: 10.1172/JCI78083. Epub 2015 May 4. Review.
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