The lymphocyte population is mainly made up of the T-lymphocytes (Thymus-Derived Lymphocytes), B-lymphocytes (bone-marrow-derived), and the NK cells (Natural-Killer Cells). T-lymphocytes mediating the cellular immunity, along with B lymphocytes mediating humoral immunity, provide adaptive immunity, which work in close collaboration with the innate immune system. B-lymphocytes mature in the bone marrow itself, while the T-lymphocytes require the thymus to mature, before being deployed to the peripheral lymphoid organs for further...
References:
-
Luckheeram RV, Zhou R, Verma AD, Xia B.
Clin Dev Immunol. 2012; 2012:925135. doi: 10.1155/2012/925135. Epub 2012 Mar 14. Review
-
Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC.
Proc Natl Acad Sci U S A. 2014 Dec 9; 111(49):17576-81. doi: 10.1073/pnas.1420936111. Epub 2014 Nov 24.
-
Ngoenkam J, Schamel WW, Pongcharoen S.
Immunology. 2018 Jan; 153(1):42-50. doi: 10.1111/imm.12809. Epub 2017 Sep 5. Review.
-
Tjon JM, Verbeek WH, Kooy-Winkelaar YM, Nguyen BH, van der Slik AR, Thompson A, Heemskerk MH, Schreurs MW, Dekking LH, Mulder CJ, van Bergen J, Koning F.
Blood. 2008 Dec 15;112(13):5103-10. doi: 10.1182/blood-2008-04-150748. Epub 2008 Sep 24.
You can view details of this pathway by subscribing: