Pathways
T-Cell Receptor and CD3 Complex
Description:
The lymphocyte population is mainly made up of the T-lymphocytes (Thymus-Derived Lymphocytes), B-lymphocytes (bone-marrow-derived), and the NK cells (Natural-Killer Cells). T-lymphocytes mediating the cellular immunity, along with B lymphocytes mediating humoral immunity, provide adaptive immunity, which work in close collaboration with the innate immune system. B-lymphocytes mature in the bone marrow itself, while the T-lymphocytes require the thymus to mature, before being deployed to the peripheral lymphoid organs for further...
References:
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CD4⁺T cells: differentiation and functions.
Clin Dev Immunol. 2012; 2012:925135. doi: 10.1155/2012/925135. Epub 2012 Mar 14. Review -
Molecular architecture of the αβ T cell receptor-CD3 complex.
Proc Natl Acad Sci U S A. 2014 Dec 9; 111(49):17576-81. doi: 10.1073/pnas.1420936111. Epub 2014 Nov 24. -
Selected signalling proteins recruited to the T-cell receptor-CD3 complex.
Immunology. 2018 Jan; 153(1):42-50. doi: 10.1111/imm.12809. Epub 2017 Sep 5. Review. -
Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3expression in enteropathy-associated T-cell lymphoma
Blood. 2008 Dec 15;112(13):5103-10. doi: 10.1182/blood-2008-04-150748. Epub 2008 Sep 24.
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