Pathways
Cellular Apoptosis Pathway
Description:
Apoptosis (also called programmed cell death) is a cellular death program that is inherent to all mammalian cells and plays an important role in the regulation of various physiological and pathological conditions. It serves to eliminate any unnecessary or unwanted cells and is a highly regulated process. There are a wide variety of conditions that will result in the apoptotic pathway becoming activated including DNA damage or uncontrolled proliferation. The apoptotic pathway is activated by both intracellular and extracellular s...
References:
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Apoptosis: A Target for Anticancer Therapy.
Int J Mol Sci. 2018 Feb 2;19(2). pii: E448. doi: 10.3390/ijms19020448. Review. -
Targeting apoptosis signaling pathways for anticancer therapy.
Front Oncol. 2011 Aug 27;1:23. doi: 10.3389/fonc.2011.00023. eCollection 2011. -
Apoptosis initiation through the cell-extrinsic pathway.
Methods Enzymol. 2014;544:99-128. doi: 10.1016/B978-0-12-417158-9.00005-4. -
Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH.
Mol Cancer. 2011 May 17;10:57. doi: 10.1186/1476-4598-10-57.
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